#Where to find kappa saphir software#

Moreover, SIRT1 is a key component in several stress-responsive pathways involved in apoptotic cell death and cellular senescence. In vascular smooth muscle cells SIRT1 enhances the activity of tissue inhibitor of metalloproteinase 3 that might stabilize atherosclerotic plaques. In endothelial cells and macrophages SIRT1 has anti-inflammatory functions by down-regulating the expression of various pro-inflammatory cytokines, interfering with the NFОєB signaling pathway, preventing macrophage foam cell formation and suppressing of endothelial tissue factor (coagulation factor III) expression. It controls vascular tone and endothelial function by deacetylation of endothelial nitric oxide synthase and by stimulating its activity. SIRT1 seems to have protective properties against atherosclerosis. Recently, their role in vascular homeostasis has been suggested.

SIRT1 and FOXO1 are evolutionary conserved regulators of aging, metabolic processes and resistance to oxidative stress. The latter was significant in women only (beta women = 0.111, p women = 0.00008 beta men = -0.009, p men = 0.6464). Several SNPs within SIRT1 showed differential effects for men and women with higher effect sizes for women: rs3740051 on all three investigated phenotypes (interaction p-value < 0.0069) rs2236319 on common and internal carotid IMT (interaction p-value < 0.0083), rs10823108, rs2273773 on common carotid IMT and rs1467568 on B-score (interaction p-value = 0.0007). One haplotype in FOXO1 showed a moderate effect on common carotid IMT and B-score in comparison to the reference haplotype of this gene. Analysis for internal carotis IMT and B-score did not reveal any significant association. Additional adjustment for traditional cardiovascular risk factors and markers (BMI, smoking status, hypertension, total cholesterol, HDL-cholesterol, hsCRP) even improved the strength of this association (p = 0.0037 for SIRT1 and p = 0.0002 for both SNPs at FOXO1). You may find me on a rare occasion wandering the ERE department in search of inspiration.A significant association was found between common carotid IMT and two SNPs at FOXO1 - rs10507486, rs2297627 (beta = -0.00168, p = 0.0007 and beta = -0.00144, p = 0.0008 respectively) and at least a trend for rs12413112 at SIRT1 (beta = 0.00177, p = 0.0157) using an additive model adjusting for age and sex. My current interests are principally in uncertainty quantification and data mining applications.

Work has taken me from Bakersfield (Mobil Oil) to Paris (Institut FranГ§ais du PГ©trole), and then bay area with Streamsim Technologies and KAPPA Engineering, where I have been working since 2014. I graduated from the Stanford Department of Petroleum Engineering with a BS (1989), MS (1994), and PhD (1997). This presentation provides an overview of these contributions, and offers to current students a small glimpse of the tremendous impact of department alumni have had in the industry over the years. Since its inception, not only has KAPPA hired many Stanford graduates, but Stanford research has made valuable, often critical contributions to KAPPAвЂ™s products and workflows.

#Where to find kappa saphir software#

KAPPA has grown significantly since then, and currently its integrated software platform (KAPPA-Workstation) is the industry standard for the analysis of dynamic data, including Pressure Transient Analysis (Saphir NL) and Rate Transient Analysis (Topaze NL). I start by introducing KAPPA Engineering, which was a start-up co-founded by a graduate of the Stanford Department of Petroleum Engineering in 1987, long before start-ups were in fashion. In fact, it may have greater impact than you imagine. This presentation offers hope to current students (in a touch-in-cheek manner) that yes, your research may indeed be useful beyond your degree and the ERE Department.

Many graduate students may wonder whether their research may one day be useful to industry. Yes, Your Research May Indeed Be Useful: Application of Stanford PE/ERE Research Ideas In KAPPA Engineering